Describing the magnitude of an excursion event as simply a high- or low-temperature event is meaningless without the factor of time. ![]() INTRODUCTION Temperature excursions happen, although organizations expend a lot of effort to avoid them. The objectives of this Stimuli article are to initiate discussion and solicit public comments regarding the new USP position on how to use MKT to evaluate temperature excursions for the shipment of pharmaceutical drugs. The authors propose using 30 days to calculate MKT for CRT products and 24 h for controlled cold temperature products, including excursion time. Correct and incorrect uses of MKT are described and supported by examples from actual events. ![]() ![]() 1 of 13 STIMULI TO THE REVISION PROCESS Stimuli articles do not necessarily reflect the policies of the USPC or the USP Council of Experts The Use of Mean Kinetic Temperature to Aid Evaluation of Temperature Excursions: Proper and Improper Application Chris Anderson,a,b Robert Seevers,a,c Desmond Hunta,d ABSTRACT This Stimuli article describes the use of mean kinetic temperature (MKT) to evaluate temperature excursions for shipments of controlled room temperature (CRT) and controlled cold temperature (CCT) pharmaceutical products. 44(4) Stimuli to the Revision Process: The Use of Mean Kinetic Tempe.
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